A2AAR/hMAO-B-IN-1 [CAS 1439488-21-7]

A2AAR/hMAO-B-IN-1 (compoudn 17) is a non-xanthine dual-target inhibitor targeting the A2A adenosine receptor (A2AAR) (IC50: 34.9 nM) andMAO-B (Ki: 39.5 nM, human) . A2AAR/hMAO-B-IN-1 inhibits A2AAR-induced cAMP accumulation and exhibits competitive, reversible inhibition of MAO-B. A2AAR/hMAO-B-IN-1 can be used in the study of neurodegenerative diseases such as Parkinson's disease (PD) [1].

[1439488-21-7]

C18H16N2O2S

324.4

O=C1SC(NC(CCCC2=CC=CC=C2)=O)=NC3=C1C=CC=C3

Adenosine Receptor; Monoamine Oxidase

99

10 mM in DMSO

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature