AAK1-IN-5 [CAS 1815613-44-5]

AAK1-IN-5 is a highly selective, CNS-penetrable, and orally active adaptor protein-2-associated kinase 1 (AAK1) inhibitor (AAK1 IC50 of 1.2 nM, Filt Ki of 0.05 nM, and cell IC50 of 0.5 nM) . AAK1-IN-4 has the potential for the research for neuropathic pain[1].

[1815613-44-5]

C19H23F4N3O

385.4

CC(C[C@](N)(COC1=CN=C(C2=CC=NC(C(F)F)=C2)C=C1C(F)F)C)C

AAK1

10 mM in DMSO

Room temperature