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Abemaciclib metabolite M18 (hydrochloride) [CAS 2704316-82-3]
Abemaciclib metabolite M18 (hydrochloride) [CAS 2704316-82-3]
SKU:QM-0141966-01
£489.83 GBP
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Product Details
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Description
Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib , is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1][2].
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CAS Number
[2704316-82-3]
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Molecular Formula
C25H29ClF2N8O
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Molecular Weight
531
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Smiles
FC(C=N1)=C(C2=CC(N(C(C)C)C(CO)=N3)=C3C(F)=C2)N=C1NC4=NC=C(C=C4)CN5CCNCC5.[H]Cl
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Target
CDK; Ligands for Target Protein for PROTAC
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Isoform
CDK4; CDK6
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Purity
98.18
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Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Abemaciclib metabolite M18 (hydrochloride) [CAS 2704316-82-3]
Abemaciclib metabolite M18 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.