ABT-724 [CAS 70006-24-5]

ABT-724, a chemical probe, is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM) . ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile[1].

[70006-24-5]

C17H19N5

293.37

C1(NC(CN2CCN(C3=NC=CC=C3)CC2)=N4)=C4C=CC=C1

Dopamine Receptor

D4 Receptor; D5 Receptor

10 mM in DMSO

Room temperature

H315-H319-H320

P264-P280-P302+P352-P305+P351+P338-P362