Ac-{Cpg}-Thr-Ala-{Ala (CO) }-Asp-{Cpg}-NH2

Ac-{Cpg}-Thr-Ala-{Ala (CO) }-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC50 values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively[1].

C31H49N7O11

695.76

CC(N[C@@H](C1CCCC1)C(N[C@@H]([C@H](O)C)C(N[C@H](C(N[C@H](C(C(N[C@H](C(N[C@@H](C2CCCC2)C(N)=O)=O)CC(O)=O)=O)=O)C)=O)C)=O)=O)=O

Parasite

10 mM in DMSO

Room temperature