Ac-DMLD-CMK (TFA)

Ac-DMLD-CMK TFA is a polypeptide targeting the mouse caspase 3-Gsdme signaling pathway. Ac-DMLD-CMK TFA can specifically inhibit the activation of caspase 3 and Gsdme. Ac-DMLD-CMK TFA blocks the cleavage of Gsdme by caspase 3, inhibits the occurrence of pyroptosis, thereby reducing renal tubular epithelial cell injury and the secretion of inflammatory cytokines. Ac-DMLD-CMK TFA reduces the levels of serum creatinine and blood urea nitrogen in mice induced by Cisplatin and alleviates the deterioration of kidney function. Ac-DMLD-CMK TFA is promising for research of chemotherapy drug-induced nephrotoxicity[1].

C24H36ClF3N4O11S

681.08

ClCC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCSC)NC([C@@H](NC(C)=O)CC(O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F

Caspase; Pyroptosis

Caspase 3

98.44

DMSO : ≥ 100 mg/mL

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Blue Ice