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Acalabrutinib-d3
Acalabrutinib-d3
SKU:QM-0121285
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Product Details
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Description
Acalabrutinib-d3 (ACP-196-d3) is the deuterated form of Acalabrutinib. Acalabrutinib (ACP-196) is an orally active, irreversible, highly selective second-generation BTK inhibitor. Acalabrutinib covalently binds to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib shows strong targeting and efficacy in mouse models of chronic lymphocytic leukemia (CLL).
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Molecular Formula
C26H20D3N7O2
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Molecular Weight
468.53
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Smiles
O=C(NC1=NC=CC=C1)C2=CC=C(C=C2)C3=C4C(N)=NC=CN4C([C@@H]5CCCN5C(C#CC([2H])([2H])[2H])=O)=N3
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Target
Isotope-Labeled Compounds
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Acalabrutinib-d3
Acalabrutinib-d3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.