Acalabrutinib (Standard) [CAS 1420477-60-6]
Acalabrutinib (Standard) [CAS 1420477-60-6]
SKU:QM-0154785-01
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Product Details
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Description
Acalabrutinib (Standard) is the analytical standard of Acalabrutinib. This product is intended for research and analytical applications. Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL) [1][2]. Acalabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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CAS Number
[1420477-60-6]
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Molecular Formula
C26H23N7O2
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Molecular Weight
465.51
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Smiles
O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2
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Target
Btk; Reference Standards
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Shipping Conditions
Room temperature
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Acalabrutinib (Standard) [CAS 1420477-60-6]
Acalabrutinib (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.