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SKU:QM-0014131-01
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ACBI-4 is a selective GTP-loaded active state of KRAS (KRAS (on) ) PROTAC degrader. ACBI-4 has significant anti-proliferative effect and potently degrades multiple KRAS mutants in cancer cells, such as KRASG12R[1].
[3097985-19-5]
C50H63N15O4S
970.2
CC([C@H](N1N=NC2=C1CC[C@H](CCCN3C[C@@H](N(CCC3)C4=NC(C5=NOC([C@@]6(C7=C(CCC6)SC(N)=C7C#N)C)=N5)=CC=N4)C)C2)C(N8C[C@@H](C[C@H]8C(NCC9=CC=C%10C(N(N=C%10)C)=C9)=O)O)=O)C
PROTACs; Ras
97.97
-20°C (Powder, sealed storage, away from moisture and light)
Blue Ice
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ACBI-4 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.