ACG548B [CAS 795316-16-4]

ACG548B (compound 24) is a potent inhibitor of acetyl- and butyrylcholinesterase (AChE and BChE) with IC50s of 1.78 and 0.496 μM, respectively. ACG548B has higher AChE affinity and selectivity over BChE and ChoK (choline kinase) . ACG548B can be uesd for the study of myasthenia gravis and neuromuscular blockade[1].

[795316-16-4]

C38H34Br2Cl2N4

777.42

CN(C1=CC=[N+](CC2=CC(C3=CC=CC(C[N+]4=CC=C(N(C5=CC=C(Cl)C=C5)C)C=C4)=C3)=CC=C2)C=C1)C6=CC=C(Cl)C=C6.[Br-].[Br-]

Cholinesterase (ChE)

AChE; BChE

99.72

DMSO : 50 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature