AChE/BChE-IN-12

AChE/BChE-IN-12 (compound 10b), a 3,5-dimethoxy analogue, is a potent AChE, BChE, and β-secretase-1 (BACE-1) inhibitor, with IC50 values of 2.57, 3.26, and 10.65 μM, respectively. AChE/BChE-IN-12 crosses the blood-brain barrier via passive diffusion and inhibits the self-aggregation of amyloid-β monomers. AChE/BChE-IN-12 can be used for Alzheimer’s disease (AD) research[1].

C23H21N3O6

435.43

COC1=CC(CN2C=C(N=N2)COC3=C(C4=C(C=C3)C=CC(O4)=O)C(C)=O)=CC(OC)=C1

Amyloid-β; Beta-secretase; Cholinesterase (ChE)

AChE; BACE1; BChE

10 mM in DMSO

Room temperature