AChE/BChE-IN-16

AChE/BChE-IN-16 (compound C7) is a potent cholinesterase (ChE) inhibitor with IC50s of 30 nM and 48 nM for human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE), respectively. AChE/BChE-IN-16 exhibits a remarkable capacity to safeguard PC12 cells against H2O2-induced apoptosis and effectively suppresses the production of reactive oxygen species (ROS) [1].

C33H34FN5O2

551.65

O=C(NCCCCCCNC1=C(C=CC(F)=C2)C2=NC3=C1CCCC3)OC4=CC=C(C(N5)=CC6=C5N=CC=C6)C=C4

Cholinesterase (ChE) ; Reactive Oxygen Species (ROS)

AChE; BChE

10 mM in DMSO

Room temperature