AChE/BuChE-IN-2 [CAS 1946008-31-6]

AChE/BuChE-IN-2 (Compound 5f) is an orally active AChE and BuChE inhibitor with IC50 values of 0.72 μM and 0.16 μM, respectively. AChE/BuChE-IN-2 shows a non-competitive inhibition with AChE and shows potent self-induced β-amyloid (Aβ) aggregation inhibition with an IC50 of 62.52 μM. AChE/BuChE-IN-2 can cross the BBB[1].

[1946008-31-6]

C20H18N2O2

318.37

C1(C2=CC=C(OCO3)C3=C2)=NC4=CC=CC=C4C(N5CCCC5)=C1

Amyloid-β; Cholinesterase (ChE)

AChE

10 mM in DMSO

Room temperature