AChE/BuChE-IN-5

AChE/BuChE-IN-5 (compound 5a) is a dual target inhibitor. AChE/BuChE-IN-5 has excellent nanomolar inhibitory activity on acetylcholinesterase (AChE) (IC50=46.9 nM) and butyryl cholinesterase (BuChE) (IC50=3.5 nM) . AChE/BuChE-IN-5 can be used for Alzheimer's Disease research[1].

C19H14N4O

314.34

C1(NC2=NN=C(O2)C3=CC(C4=CC=CC=C4)=CN=C3)=CC=CC=C1

Cholinesterase (ChE)

AChE; BChE

10 mM in DMSO

Room temperature