AChE/GSK-3β-IN-1 [CAS 2412364-73-7]
AChE/GSK-3β-IN-1 [CAS 2412364-73-7]
SKU:QM-0068884
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Product Details
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Description
AChE/GSK-3β-IN-1 (compound GT15) is a potent, dual AChE/GSK-3β inhibitor with IC50 values of 1.2, 149.8 and 22.4 nM for hAChE , hBChE and hGSK-3β, respectively. AChE/GSK-3β-IN-1 penetrates the blood-brain barrier (BBB) . AChE/GSK-3β-IN-1 has high kinase selectivity profiles for the CMGC kinase family. AChE/GSK-3β-IN-1 occupies the ATP binding site of DYRK1A. AChE/GSK-3β-IN-1 inhibits ROS expression and reduces oxidative stress. AChE/GSK-3β-IN-1 can be used for Alzheimer’s disease research[1].
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CAS Number
[2412364-73-7]
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Molecular Formula
C31H35N7O3S
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Molecular Weight
585.72
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Smiles
CNC(C(S1)=C(N=C1C2=CC(NC(CNCCNC3=C4CCCCC4=NC5=CC=CC=C35)=O)=NC=C2)OCC6CC6)=O
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Target
Cholinesterase (ChE) ; GSK-3; Microtubule/Tubulin; ROS Kinase
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Isoform
AChE
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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AChE/GSK-3β-IN-1 [CAS 2412364-73-7]
AChE/GSK-3β-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.