AChE-IN-14 [CAS 2390042-05-2]

AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC50s of 0.46, 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H3 receptor (H3R; Ki= 159.8 nM) . AChE-IN-14 can be used for the research of Alzheimer’s disease[1].

[2390042-05-2]

C28H35NO3

433.58

O=C1C=C(C2=CC=C(OCCCCCCN3CCCCCC3)C=C2)OC4=CC=C(C)C=C14

Cholinesterase (ChE) ; Histamine Receptor

AChE

10 mM in DMSO

Room temperature