AChE-IN-34

AChE-IN-34 (compound 5l) is a potent and selective AChE inhibitor with an IC50 value of 3.98 µM with no significant inhibition against BChE. AChE-IN-34 inhibits AChE with a Ki of 0.044 μM in a mixed mode (Acetylthiocholine substrate; 0.1-1 mM) [1].

C19H14N8O6

450.36

NC1=C(C#N)C2(C3=C(NC2=O)C=CC([N+]([O-])=O)=C3)C([N+]([O-])=O)=C(NC4=CC=C(O)C=C4)NN1

Cholinesterase (ChE)

AChE

10 mM in DMSO

Room temperature