AChE-IN-5

AChE-IN-5 (compound 5) exhibits strong in vitro bioactivity against AChE/5-HT1A/SERT and exhibits good BBB permeability. AChE-IN-5 shows IC50 value 2.29 nM against AChE, EC50 value 58.6 nM against 5-HT1A and IC50 value against SERT. Orally active[1].

C38H45N5O

587.8

N#CC1=CC2=C(NC=C2CCCCN3CCN(CC3)C4=CC=C(C=C4)C(CCC5CCN(CC5)CC6=CC=CC=C6)=O)C=C1

5-HT Receptor; Cholinesterase (ChE) ; Serotonin Transporter

5-HT1 Receptor; AChE

10 mM in DMSO

Room temperature