AChE-IN-63 [CAS 876685-78-8]

AChE-IN-63 (Compound 5AD) is a selective inhibitor of hAChE (IC50=0.103 μM) . AChE-IN-63 also inhibits hBChE and hBACE-1 (IC50= 10 μM (hBChE) ; 1.342 μM (hBACE-1) ) . AChE-IN-63 inhibits Aβ aggregation, preventing the formation and deposition of Aβ1-42. AChE-IN-63 can effectively penetrate the blood-brain barrier and is orally effective. It is primarily used in Alzheimer's disease research[1].

[876685-78-8]

C18H19N5O

321.38

C1(C2=NN=C(O2)CN3CCN(CC3)C4=CC=CC=N4)=CC=CC=C1

Amyloid-β; Beta-secretase; Cholinesterase (ChE)

AChE; BChE

10 mM in DMSO

Room temperature