AChE-IN-9

AChE-IN-9 is a Tacrine glycoconjugate tethered with acetylated β-Glucose. AChE-IN-9 is also an AChE inhibitor with an IC50 value of 0.4 μM, with lower hepatotoxicity on healthy cells. Tacrine is used in Alzheimer's research[1].

C30H35N5O9

609.63

CC(OC[C@H]1O[C@@H]([C@@H]([C@H]([C@@H]1OC(C)=O)OC(C)=O)OC(C)=O)N2C=C(N=N2)CNC3=C4CCCCC4=NC5=CC=CC=C53)=O

Cholinesterase (ChE)

AChE

10 mM in DMSO

Room temperature