(+/-) -Adomeglivant [CAS 872260-47-4]

(+/-) -Adomeglivant ((+/-) -LY2409021) is a potent and selective glucagon receptor antagonist with hypoglycemic activity. (+/-) -Adomeglivant is effective in lowering blood sugar levels in both healthy people and people with type 2 diabetes. (+/-) -Adomeglivant is well tolerated by glucagon signaling blockade in patients with type 2 diabetes and significantly reduces fasting and postprandial blood glucose with a concomitant reversible elevation of aminotransferases. Glucagon signaling inhibition by (+/-) -Adomeglivant is a promising potential inhibitory approach for patients with type 2 diabetes and warrants further evaluation of its benefits and risks in longer clinical trials[1].

[872260-47-4]

C32H36F3NO4

555.63

O=C(CCNC(C1=CC=C(C(CCC(F)(F)F)OC2=CC(C)=C(C3=CC=C(C(C)(C)C)C=C3)C(C)=C2)C=C1)=O)O

Endogenous Metabolite

Room temperature