Afabicin [CAS 1518800-35-5]

Afabicin (Debio 1450) is the proagent of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.

[1518800-35-5]

C23H24N3O7P

485.43

O=P(O)(O)OCN1C2=NC=C(/C=C/C(N(C)CC(OC3=CC=CC=C43)=C4C)=O)C=C2CCC1=O

Bacterial

96.28

H2O : 3.85 mg/mL (ultrasonic; warming; adjust pH to 10 with NaOH; heat to 60°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature