Afatinib (dimaleate) [CAS 850140-73-7]

Afatinib (BIBW 2992) dimaleate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib dimaleate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer[1][2][3][4].

[850140-73-7]

C32H33ClFN5O11

718.08

O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[C@H]4CCOC4)/C=C/CN(C)C.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O

Akt; Apoptosis; Autophagy; c-Met/HGFR; EGFR; p38 MAPK

EGFR/ErbB1/HER1; ErbB2/HER2; ErbB3/HER3

99.74

DMSO : ≥ 35 mg/mL|H2O : 50 mg/mL (ultrasonic)

4°C (Powder, sealed storage, away from moisture)

Room Temperature

H302, H319, H373

H302, H319, H373