AG01 is a monoclonal antibody against progranulin (GP88) . AG01 inhibits triple-negative breast cancer (TNBC) cell proliferation and migration, reduces the expression of phosphorylated protein kinases p-Src, p-AKT, and p-ERK, and reduces the expression of oncogenic proteins such as Axl, c-MET, HIF-1α, and VEGF. AG01 inhibits tumor growth and Ki67 expression in a TNBC xenograft mouse model. AG01 can be used in the research of TNBC and other cancers[1].
Target
Akt; c-Met/HGFR; ERK; HIF/HIF Prolyl-Hydroxylase; MMP; Src; TAM Receptor; VEGFR
