AGI-14100 [CAS 1448346-43-7]

AGI-14100 is a metabolically stable and orally available mIDH1 inhibitor (IC50=6 nM) . The pharmacochemical optimization of AGI-14100 is aimed at eliminating hPXR activation, resulting in the final drug candidate AG-120. AG-120 can be used in the study of cancers carrying IDH1 mutations. The discovery and development of AGI-14100 can be used for further studies of mutant isocitrate dehydrogenase 1 (mIDH1) inhibitors[1].

[1448346-43-7]

C29H22ClF4N5O3

599.96

O=C([C@@H](N1C2=NC=CC(C#N)=C2)CCC1=O)N([C@@H](C3=CC=CC=C3Cl)C(NC4CC(C4)(F)F)=O)C5=CC(F)=CC(F)=C5

Isocitrate Dehydrogenase (IDH)

10 mM in DMSO

Room temperature