AH078

AH078 (compound 37) is a PROTAC degrader that selectively targets CK1δ and CK1ε, and has low targeting for CK1α. AH078 consists of PROTAC linker (black part) Monomethyl octanoate , target protein ligand (red part) (HY-170860) CK1δ/CK1ε liagnd-1 and E3 ligase ligand (blue part) E3 ligase Ligand 58 (HY-170861). Among them, E3 ligase ligand + linker can form a conjugate E3 Ligase Ligand-linker Conjugate 163 (HY-170862).

C51H60F2N10O5S

963.15

O=C([C@H]1N(C([C@@H](NC(CCCCCCC(N2CCC(CN3C(C4=C5C(NC=C5)=NC=C4)=C(C6=NC=C(F)C=C6)N=C3)(F)CC2)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7

Casein Kinase

Room temperature