AK963/40708899 [CAS 445007-59-0]

AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways[1].

[445007-59-0]

C16H18N2O

254.33

O=C(NC1=CC(C)=CC=C1C)NC2=CC=CC(C)=C2

PAK

PAK1

Room temperature