AKR1C3-IN-14 [CAS 1057882-82-2]

AKR1C3-IN-14 (compound 4) is an AKR1C3 inhibitor (IC50=0.122 μM) that reduces the overproduction of androgens by inhibiting the activity of the AKR1C3 enzyme, thereby regulating hormone-mediated signaling. AKR1C3-IN-14 also plays a role in the biosynthesis of the prostaglandin PGF2α, regulating cell proliferation by affecting this pathway. AKR1C3-IN-14 can be used in the study of prostate cancer[1].

[1057882-82-2]

C21H21BrN2O4

445.31

O=C(NC1=CC=C(Br)C=C1C)CN(C)CC(C2=C(O3)C(C)=C(O)C=C2)=CC3=O

Aldose Reductase

Room temperature