AKR1C3-IN-15 [CAS 3059671-44-9]

AKR1C3-IN-15 (compound 30) is a potent and selective AKR1C3 inhibitor with an IC50 of 5 nM. AKR1C3-IN-15 enhances Sorafenib -induced ROS generation, promoted apoptosis, and restored sorafenib sensitivity in HCC models both in vitro and in vivo[1].

[3059671-44-9]

C19H16FNO4

341.33

O=C(C1=CC2=C(C=C(C=C2)F)OC1)N(CC3=CC=C(C=C3)C(O)=O)C

Aldose Reductase; Apoptosis

Room temperature