Akuammine [CAS 3512-87-6]

Akuammine is an indole alkaloid that has been found in Picralima nitida and has analgesic activity. It selectively binds to the μ- and κ-opioid receptors over the δ-opioid receptor (Kis=0.3, 1.68, and 10.4 μM for the human receptors, respectively) . Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC50s=2.6 and 0.073 μM, respectively) . It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg.

[3512-87-6]

C22H26N2O4

382.45

COC([C@]12C34[C@]([C@]5([H])CC2/C(CN5CC3)=C\C)(N(C)C6=C4C=C(O)C=C6)OC1)=O

Others

Room temperature