[Ala11, D-Leu15]-Orexin B (human) [CAS 532932-99-3]

[Ala11, D-Leu15]-Orexin B (human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11, D-Leu15]-Orexin B (human) shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (52 nM) [1].

[532932-99-3]

C120H206N44O35S

2857.26

C(=O)([C@H]1N(C(CNC([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CO)=O)=O)CCC1)N2[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC3=CN=CN3)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)[C@@H](C)O)=O)CC(C)C)=O)[C@H](CC)C)=O)=O)C)=O)C)=O)=O)CC(N)=O)=O)=O)CO)=O)C)=O)CCC(N)=O)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)C)=O)CCCNC(=N)N)=O)=O)CCC(N)=O)=O)CC(C)C)=O)=O)CCC2

Orexin Receptor (OX Receptor)

OX1 Receptor; OX2 Receptor

98.31

10 mM in DMSO

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

Blue Ice