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Alisertib [CAS 1028486-01-2]

Alisertib [CAS 1028486-01-2]

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QM-0136582-01

£108.25 GBP
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Product Details

  • Description

    Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor (IC50=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity[1][2][3].

  • CAS Number

    [1028486-01-2]

  • Molecular Formula

    C27H20ClFN4O4

  • Molecular Weight

    518.92

  • Smiles

    O=C(C1=CC=C(C=C1OC)NC2=NC=C3CN=C(C4=CC(Cl)=CC=C4C3=N2)C5=C(C=CC=C5F)OC)O

  • Target

    Apoptosis; Aurora Kinase; Autophagy

  • Isoform

    Aurora A; Aurora B

  • Purity

    99.84

  • Solubility

    DMSO : 25 mg/mL (ultrasonic)

  • Storage Conditions

    -20°C, 3 years; 4°C, 2 years (Powder)

  • Shipping Conditions

    Room Temperature

  • Hazard Statement

    H302, H312, H332

  • Precautions

    H302, H312, H332
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Variant Variant total Quantity Price Variant total
5 mgQM-0136582-01
5 mgQM-0136582-01
£108.25/ea		 £0.00
£108.25/ea £0.00
10 mM - 1 mLQM-0136582-02
10 mM - 1 mLQM-0136582-02
£120.63/ea		 £0.00
£120.63/ea £0.00
10 mgQM-0136582-03
10 mgQM-0136582-03
£200.66/ea		 £0.00
£200.66/ea £0.00
50 mgQM-0136582-04
50 mgQM-0136582-04
£414.50/ea		 £0.00
£414.50/ea £0.00
100 mgQM-0136582-05
100 mgQM-0136582-05
£614.98/ea		 £0.00
£614.98/ea £0.00
200 mgQM-0136582-06
200 mgQM-0136582-06
£1,116.77/ea		 £0.00
£1,116.77/ea £0.00
500 mgQM-0136582-07
500 mgQM-0136582-07
£1,556.60/ea		 £0.00
£1,556.60/ea £0.00
1 gQM-0136582-08
1 gQM-0136582-08
£2,083.91/ea		 £0.00
£2,083.91/ea £0.00
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Alisertib [CAS 1028486-01-2]

Alisertib is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.