ALK-IN-31 [CAS 3043840-25-8]

ALK-IN-31 (Compound Ld-10) is an orally active ALK inhibitor (IC50: 1135 nM) . ALK-IN-31 exhibits excellent antiproliferative activity against lung cancer H2228 cells with an IC50 value of 1.35 μM. ALK-IN-31 induces apoptosis and arrests cell proliferation in the G0/G1 phase by affecting mitochondrial function. ALK-IN-31 exerts its anti-tumor effect by downregulating the expression of p-AKT and p-mTOR in the PI3K-AKT-mTOR signaling pathway downstream of ALK. ALK-IN-31 can be used in the study of non-small cell lung cancer (NSCLC) [1].

[3043840-25-8]

C30H33N5O2S

527.68

O=C(C1CCCCC1)NC2=CC=CC=C2NC3=C(CSCC4)C4=NC(NC(C=C5CCC6)=CC=C5C6=O)=N3

Akt; Anaplastic lymphoma kinase (ALK) ; Apoptosis; mTOR

Room temperature