ALK-IN-6 [CAS 2055821-33-3]

ALK-IN-6 (compound 11) is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK), with IC50 values of 71 nM, 18.72 nM and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L, respectively[1].

[2055821-33-3]

C26H29D3ClN5O3S

533.1

ClC1=CN=C(NC2=C(OC([2H])([2H])[2H])C=C(C3CCNCC3)C(C)=C2)N=C1NC4=CC=CC=C4S(=O)(C(C)C)=O

Anaplastic lymphoma kinase (ALK)

10 mM in DMSO

Room temperature