ALKBH1-IN-3

ALKBH1-IN-3 is a potent DNA N6-methyladenine (6mA) demethylase ALKBH1 inhibitor. ALKBH1-IN-3 increases the abundance of 6mA, inhibits cell viability and upregulates the AMP-activated protein kinase (AMPK) signaling pathway in gastric cancer cell lines HGC27 and AGS. ALKBH1-IN-3 is promising for research of cancers, including gastric cancer[1].

C16H14N4O4

326.31

OC(C1=CN(N=C1)C2=NC=C(C=N2)OCC3=CC(OC)=CC=C3)=O

AMPK

Room temperature