Alloc-Val-Ala-OH [CAS 330970-70-2]

Alloc-Val-Ala-OH (((Allyloxy) carbonyl) -L-valyl-L-alanine) is a building block in the synthesis of Tesirine, a clinical antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.

[330970-70-2]

C12H20N2O5

272.3

OC([C@H](C)NC([C@H](C(C)C)NC(OCC=C)=O)=O)=O

Biochemical Assay Reagents

99.75

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H315, H319

H315, H319