Alvimopan (dihydrate) [CAS 170098-38-1]

Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan dihydrate has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively) . Alvimopan dihydrate can be used for the research of postoperative ileus[1][2][3].

[170098-38-1]

C25H36N2O6

460.56

OC1=CC=CC([C@@]2(C)[C@@H](C)CN(C[C@H](CC3=CC=CC=C3)C(NCC(O)=O)=O)CC2)=C1.O.O

Opioid Receptor

μ Opioid Receptor/MOR

10mM

98.66

DMSO : 33.33 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302, H312, H332

H302, H312, H332