AM-0687 [CAS 1259522-94-5]

AM-0687 is a selective inhibitor for PI3Kδ with an IC50 of 2.9 nM. AM-0687 decreases the levels of IgG and IgM specific antibodies, inhibits the anti-IgM/CD40L-induced proliferation of human B cell (IC50=0.8 nM) and the phosphorylation of AKT (IC50=0.7 nM), and exhibits anti-inflammatory efficacy[1].

[1259522-94-5]

C23H19FN8O

442.45

O=C(C1=C(C2=NC=CC=C2)C([C@@H](NC3=NC=NC(N)=C3C#N)C)=NC4=CC=C(F)C=C14)NC

PI3K

PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

Room temperature

H302-H315-H319-H335

P261-P280-P302+P352