AM-3189 [CAS 916219-50-6]

AM-3189 is an orally active and selective GPR40 agonist with EC50 values in buffer solution and in 100% human serum of 33 nM and 10 μM respectively. AM-3189 shows no significant activity on GPR41 and GPR43, and no agonistic activity on PPAR-α, -δ, and -γ. AM-3189 enhances glucose-stimulated insulin secretion by activating GPR40 on pancreatic β cells. AM-3189 has extremely low penetration into the central nervous system and significantly reduces blood glucose levels in two humanized GPR40 mouse models. AM-3189 can be used for the study of type 2 diabetes[1].

[916219-50-6]

C27H25ClN2O3

460.95

OC(C[C@H](C1=NC=CN1C)C2=CC=C(C=C2)OCC3=CC(C4=C(C=C(C=C4)Cl)C)=CC=C3)=O

Free Fatty Acid Receptor

Room temperature