AM841 [CAS 871978-21-1]

AM841 is a high-affinity electrophilic ligand. AM841 interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor. AM841 reduces Forskolin -stimulated cAMP accumulation. AM841 also slows gastrointestinal motility[1][2].

[871978-21-1]

C26H39NO3S

445.66

OC1=C2[C@@]3([H])[C@](CC[C@H](C3)CO)([H])C(C)(OC2=CC(C(C)(C)CCCCCCN=C=S)=C1)C

Cannabinoid Receptor

10 mM in DMSO

Room temperature