AMG-076 (free base) [CAS 693823-79-9]

AMG-076 free base is an orally bioavailable and selective MCHR1 antagonist. AMG-076 free base results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice[1].

[693823-79-9]

C26H33F3N2O2

462.55

O=C(C1(CCN2CC[C@]3([H])CC(NC4=C5C=C(C(F)(F)F)C=C4)=C5[C@H](C)[C@@]3([H])C2)CCCCC1)O

MCHR1 (GPR24)

Room temperature