AMG 7905 [CAS 1026876-55-0]

AMG 7905 is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. AMG 7905 potentiates TRPV1 channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin[1][2].

[1026876-55-0]

C25H24F3N5S

483.55

FC(F)(C1=CC(NCC2CCCCC2)=C(C3=CC(NC4=CC5=C(N=CS5)C=C4)=NC=N3)C=C1)F

TRP Channel

90.93

-20°C, 3 years (Powder)

Blue Ice