AMG8379 [CAS 1642112-31-9]

AMG8379 is a potent, orally active and selective sulfonamide antagonist of the voltage-gated sodium channel NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively. AMG8379 potently and reversibly blocks endogenous Tetrodotoxin (TTX) -sensitive sodium channels in dorsal root ganglia (DRG) neurons with an IC50 of 3.1 nM[1].

[1642112-31-9]

C25H16ClF2N3O5S

543.93

O=S(NC1=NOC=C1)(C2=CC(C=CC(N3C4=C(OC)C=C(C(F)=C4)C5=CC(Cl)=CC(F)=C5)=O)=C3C=C2)=O

Sodium Channel

Nav1.7

10 mM in DMSO

Room temperature