Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3. Amino-PEG3-C2-Azido is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
[134179-38-7]
Molecular Formula
C8H18N4O3
Molecular Weight
218.25
Smiles
[N-]=[N+]=NCCOCCOCCOCCN
Target
PROTAC Linkers
Purity
99.67
Solubility
10 mM in DMSO
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)