Amorphigenin [CAS 4208-09-7]

Amorphigenin is a trothotenone compound. Amorphigenin inhibits osteoclast differentiation by suppressing the expression of c-Fos and NFATc1 in activated T cells. Amorphigenin degrades melanosome proteins by activating the AMPK-dependent autophagy pathway, but not in dependence of the mTOR pathway. Amorphigenin significantly protects bone mass and reduces bone erosion in a mouse model of inflammatory bone loss. Amorphigenin can be used to study inflammatory bone diseases, postmenopausal osteoporosis, and skin pigmentation disorders[1][2].

[4208-09-7]

C23H22O7

410.42

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AMPK; AP-1; Autophagy; Nuclear Factor of activated T Cells (NFAT)

C-Fos

Room temperature