Ampiroxicam [CAS 99464-64-9]
Ampiroxicam [CAS 99464-64-9]
SKU:QM-0154622-01
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Product Details
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Description
Ampiroxicam (CP65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. Target: COX Ampiroxicam is a non-steroidal anti-inflammatory drug. It is a prodrug of piroxicam. Ampiroxicam inhibits the stretching response in mice induced by phenylbenzoquinone (PBQ) with maximum protective effect (MPE) of 2 mg/kg. Ampiroxicam inhibits swelling in a dose-responsive manner in the rat foot edema (RFE) assay with ED50 of 28 mg/kg at single oral dose and 7.8 mg/kg at 5 daily oral dose. Ampiroxicam blocks primary and secondary lesion development in rat adjuvant arthritis with ED50 of 2.2 mg/kg and 0.5 mg/kg, respectively. Ampiroxicam (3.2 mg/kg) leads to a plasma concentration of 12 μg/mL at a Tmax of 2 hours for piroxicam derived from ampiroxicam in rats [1]. Ultraviolet-A (UVA) -irradiated 1% Ampiroxicam sensitized in guinea pigs shows positive reaction in the patch testing to UVA-irradiated 1% Ampiroxicam and 1% thiosalicylate (TOS) . Concentration of Ampiroxicam is easily reduced by the increase in UVA irradiation doses, as compared with that of piroxicam [2].
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CAS Number
[99464-64-9]
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Molecular Formula
C20H21N3O7S
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Molecular Weight
447.46
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Smiles
O=C(OC(OC(C1=CC=CC=C12)=C(C(NC3=NC=CC=C3)=O)N(C)S2(=O)=O)C)OCC
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Target
COX
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Isoform
COX
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Purity
98.73
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Solubility
DMSO : 50 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Ampiroxicam [CAS 99464-64-9]
Ampiroxicam is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.