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β-Amyloid (1-42), human, Ala (13C3,15N) (TFA)

β-Amyloid (1-42), human, Ala (13C3,15N) (TFA)

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QM-0025750-01

£1,279.58 GBP
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Product Details

  • Description

    β-Amyloid (1-42), human, Ala (13C3,15N) TFA is the 13C and 15N-labeled β-Amyloid (1-42), human. β-Amyloid (1-42) (Amyloid β-peptide (1-42) ), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death[1][1][2][3][4][5][6][7].

  • Molecular Formula

    C200 13C3H311N54 15NO60S

  • Molecular Weight

    4518.01

  • Smiles

    OC(C(F)(F)F)=O.O=C([15NH][13C@@H]([13CH3])[13C](N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(NCC(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CC7=CC=CC=C7)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(NCC(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H](C(C)C)C(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N.[x]

  • Target

    Amyloid-β; Isotope-Labeled Compounds

  • Purity

    99.57

  • Storage Conditions

    -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

  • Shipping Conditions

    Blue Ice
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Variant Variant total Quantity Price Variant total
1 mgQM-0025750-01
1 mgQM-0025750-01
£910.80
£1,279.58/ea
 £0.00
£910.80
£1,279.58/ea
 £0.00
5 mgQM-0025750-02
5 mgQM-0025750-02
£2,324.70
£3,188.34/ea
 £0.00
£2,324.70
£3,188.34/ea
 £0.00
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β-Amyloid (1-42), human, Ala (13C3,15N) (TFA)

β-Amyloid (1-42), human, Ala (13C3,15N) (TFA) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.