And1 degrader 1 [CAS 3029132-46-2]

And1 degrader 1 (Compound A15) is a degrader of the acidic nucleoplasmic DNA-binding protein 1 (And1), which can significantly induce the degradation of And1 in NSCLC cells. And1 degrader 1 (5 μM) combined with Olaparib (1 μM) effectively inhibits the proliferation of A549 and H460 cells. And1 degrader 1 can be used in cancer research[1].

[3029132-46-2]

C26H27Cl2N3O

468.42

OC1=CC=C(/C=C/C2=CC=C(Cl)C(Cl)=C2)C=C1CNC3=CC=C(N4CCN(C)CC4)C=C3

DNA/RNA Synthesis

Room temperature