Anti-MRSA agent 7 [CAS 9007-83-4]

Anti-MRSA agent 7 (Compound 12) is a potent antibacterial agent. Anti-MRSA agent 7 inhibits S. aureus DNA gyrase, E. coli DNA gyrase, S. aureus topo IV and E. coli topo IV with IC50s of 0.185, 0.365, 0.341 and 0.059 μM, respectively[1].

[9007-83-4]

C22H20BrF2N3O4

508.31

COC1=NC2=C(N=CC=C2OC[C@H]3CC[C@@H](CO3)NC(C4=CC(F)=C(C(F)=C4)Br)=O)C=C1

Bacterial; DNA/RNA Synthesis; Topoisomerase

Topoisomerase

10 mM in DMSO

Room temperature