Anti-NASH agent 1 [CAS 2409685-41-0]

Anti-NASH agent 1 (compound 3d), a derivative of Elafibranor , is a potent agonist of PPAR-α/δ, targeting to nonalcoholic steatohepatitis (NASH). Anti-NASH agent 1 (3-10 mg/kg; 4 weeks) improves hyperlipidemia, liver fat degeneration and liver inflammation in Methionine-choline deficiency (MCD) induced NASH mice model. Anti-NASH agent 1 shows low liver toxicity and potent liver protection effect[1].

[2409685-41-0]

C26H33NO4

423.54

CC(C)(OC1=C(C)C=C(/C=C/C(C2=CC=C(NC)C=C2)=O)C=C1C)C(OC(C)(C)C)=O

PPAR

98.49

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature